Nrf2´s role in myocardial ischemia & reperfusion injury
The morbidity rate of myocardial ischemia and reperfusion has grown in contemporary times, and oxidative stress plays a crucial role in the pathological procedure. Atomic variable E2-associated factor 2 (Nrf2) is regarded as a critical regulator for maintaining the redox equilibrium and is involved from the initiation of this transcriptional expression of downstream antioxidant enzymes. Moreover, Nrf2 can also be controlled in a variety of ways. Nrf2/Keap1/ARE is just one of those vital signaling pathways which could attenuate myocardial infarct size and maintain cardiac function after myocardial ischemia and reperfusion injury (MIRI). Nrf2 activation offers cardioprotection through the coordinated up-regulation of anti-inflammatory, antioxidant, and autophagy mechanisms. Various studies have demonstrated that ischemic preconditioning and ischemic post-conditioning possess a clear protective influence on MIRI, and the prospective function of this Nrf2 signaling pathway in cardioprotection could be well worth talking about. This review will outline the present knowledge regarding the regulation of and participation of Nrf2 in MIRI.
Keywords: gastrointestinal program; Myocardial ischemia-reperfusion harm; Nrf2; Oxidative stress; Preconditioning and post-conditioning.