Luteolin

Luteolin is a naturally-occurring flavonoid, together with possible anti inflammatory, anti inflammatory, apoptosis-inducing and chemopreventive actions. Upon government, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and causes direct cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and inhibits metastasis.Luteolin, also referred to as digitoflavone or flacitran, belongs to the category of natural compounds called flavones. These are flavonoids using a construction based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Therefore, luteolin is regarded as a flavonoid lipid molecule. Luteolin is present as a strong and is regarded as virtually insoluble (in water) and comparatively impartial. Luteolin has been mostly detected in bloodcirculation. Within the mobile, luteolin is largely found in the membrane (called from logP). Luteolin can also be a parent chemical for additional transformation products, such as but not restricted to, 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucosylluteolin, carlinoside, and luteolin 6-C-[beta-D-glucosyl-(1->2)-alpha-L-arabinoside]. Luteolin is a bitter tasting chemical which may be located in several of food items like cocoa, coconut, oyster mushroom, and black salsify. This creates luteolin a possible biomarker for the intake of those food products.Luteolin is a tetrahydroxyflavone where the four hydroxy bands are situated in positions 3′, 4′ 7 and 5. It’s supposed to play a significant function in the human body as an antioxidant, a free radical scavenger, an inflammatory agent and also an immune system modulator in addition to being active against many cancers. It’s a function as a EC 2.3.1.85 (fatty acid synthase) inhibitor, an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a plant metabolite, a nephroprotective representative, an angiogenesis inhibitor, a c-Jun N-terminal kinase inhibitor, an antioxidant, an anti-inflammatory agent as well as an apoptosis inducer. It’s a 3′-hydroxyflavonoid plus also a tetrahydroxyflavone. It’s a conjugate acid of a two -(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-).

ChEBIResource: ChEBIRecord

Title: Luteolin

URL: http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15864

Description: Chemical Entities of Biological Interest (ChEBI) is a database and ontology of molecular entities centered on’little’ chemical compounds, That’s part of the Open Biomedical Ontologies effort.