GNM-X
GNM-X (PB123) Study
ESTUDIO CIENTÍFICO SOBRE PB123 Descargar Estudio en PDF Abstract. There has been a long history of human usage of the biologically-active phytochemicals in Salvia rosmarinus, Zingiber officinale, and Sophora japonica for health purposes, and we recently reported on a combination of those plant materials as the PB123 dietary supplement. In the present work we extended …
Professor Helmut Sies, the Redox pioneer
Dr. Helmut Sies (MD, 1967) is known as a Redox Pioneer, since he authored five posts on oxidative stress, lycopene, and chromium, every one of which was cited more than 1000 days, and coauthored a post about how hydroperoxide metabolism in mammalian techniques cited over 5000 days (Google Scholar). He acquired preclinical education in the …
Nrf2-Deficient Mice show Unfavorable Immune Signature in Advanced Lung Tumors
Aims: Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in normal cells inhibits carcinogenesis, whereas constitutive activation of Nrf2 in cancer cells promotes tumor growth and chemoresistance. However, the consequences of Nrf2 activation in cells during lung carcinogenesis are poorly characterized and may either promote or inhibit cancer growth. Our studies were designed …
Nrf2 inhibits NLRP3 inflammasome activation in cerebral injury
The nod-like receptor protein (NLRP3) inflammasome includes a important function in inflammation harm in irreparable injury, and also the activation of the inflammasome is closely linked to the interaction with thioredoxin interacting protein (TXNIP), which dissociates in the thioredoxin1 (Trx1)/TXNIP complicated under oxidative stress. On the other hand, the negative regulator of NLRP3 inflammasome activation …
Nrf2 suppresses lupus nephritis via inhibition of oxidative injury & the NF-κB-mediated inflammatory Reaction
The production of reactive oxygen species plays a critical role in both chronic and acute glomerular accidents in patients with lupus nephritis. Since the transcription factor Nrf2 is a significant regulator of the antioxidant reaction and is a main cell defense mechanism, we sought to ascertain a part of Nrf2 in the development of lupus …
The Anti-Inflammatory and Anti-Oxidant Mechanisms of This Keap1/Nrf2/ARE Signaling Pathway in Allergic Disorders
Oxidative stress is defined as an imbalance between generation of free radicals and reactive metabolites or [reactive oxygen species (ROS)] and their removal through protective mechanisms, such as (antioxidants). This imbalance contributes to damage of tissues and significant biomolecules and cells, together with consequently posing a possible negative effect on the entire organism. In the …
Activation of NRF2 Helps Lethal Autoimmune Inflammation in Scurfy Mice
The transcription factor NRF2 (nuclear factor [erythroid-derived 2]-like two ) plays critical roles in the defense mechanisms against oxidative stress and mediates anti inflammatory activities under different pathological conditions. Recent research demonstrated that the breakdown of regulatory T cells (Tregs) is linked to the initiation and development of various autoimmune disorders. To ascertain the Treg-independent …
Transcription Factor NRF2 as a Therapeutic Target for Bipolar Disorders: A Systems Medicine Approach
Systems medicine has a mechanism-based rather than a symptom- or – organ-based approach to disease and explains therapeutic goals in a nonhypothesis-driven manner. In this function, we employ this to transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) by cross-validating its position in a protein-protein interaction network (the NRF2 interactome) functionally linked to cytoprotection in …
The Keap1-Nrf2: Mechanisms of activation and dysregulation in cancer
The Keap1-Nrf2 pathway is the significant regulator of cytoprotective responses to oxidative and electrophilic anxiety. Although mobile signaling pathways triggered by the transcription factor Nrf2 stop cancer initiation and development in normal and premalignant cells, in completely cancerous cells Nrf2 activity offers growth advantage by boosting cancer chemoresistance and improving tumor cell development. Within this …
The Role of Nrf2: Oxidative Stress and Cancer
Oxidative stress because of imbalance between ROS detoxification and production plays a critical role in determining cell fate. In reaction to this excess ROS, apoptotic signaling pathway is triggered to promote normal cell death. But through deregulation of biomolecules, higher quantity of ROS promotes carcinogenesis in cells with faulty signaling variables. Within this line, NRF2 …
The many roles of Nrf2 in mitochondrial function
The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the master regulator of the cellular redox homeostasis. Nrf2 target genes include a massive system of antioxidant enzymes, proteins involved in xenobiotic detoxification, removal and repair of damaged proteins, inhibition of inflammation, in addition to other transcription factors. In the past few years …
Nrf2´s role in myocardial ischemia & reperfusion injury
The morbidity rate of myocardial ischemia and reperfusion has grown in contemporary times, and oxidative stress plays a crucial role in the pathological procedure. Atomic variable E2-associated factor 2 (Nrf2) is regarded as a critical regulator for maintaining the redox equilibrium and is involved from the initiation of this transcriptional expression of downstream antioxidant enzymes. …
Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury
Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury Bioactive phytochemicals at Rosmarinus officinalis, Withania somnifera, and Sophora japonica have a very long history of human usage to promote wellbeing. In this research we analyzed the ramifications of a blend of extracts from such plant sources based on predetermined amounts …/p>
Respiratory protease/antiprotease Equilibrium determines susceptibility to viral infection and May be Altered by nutritional antioxidants
The respiratory epithelium acts as a fundamental orchestrator to organize and initiate responses to inhaled stimulation. Proteases and antiproteases are secreted in the respiratory epithelium and therefore are involved in respiratory homeostasis. Changes into the protease/antiprotease equilibrium may result in the evolution of lung ailments like emphysema or chronic obstructive pulmonary disorder. What’s more, altered …
Luteolin
Luteolin is a naturally-occurring flavonoid, together with possible anti inflammatory, anti inflammatory, apoptosis-inducing and chemopreventive actions. Upon government, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and causes direct cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and inhibits metastasis.Luteolin, also referred to as digitoflavone or …
Phytochemical mix PB125 Activates the Nrf2 Pathway reulting in Cellular Protection against Oxidative Stress
Bioactive phytochemicals at Rosmarinus officinalis, Withania somnifera, and Sophora japonica have a very long history of human usage to promote wellbeing. In this research we analyzed the ramifications of a blend of extracts from such plant resources based on specified amounts of the carnosol/carnosic acid, withaferin A, and luteolin amounts, respectively. These bioactive compounds have …