Irritable Bowel Infection Is Associated with a Higher Risk of Dementia

A Nationwide Population-Based Study AbstractGoal Irregular interaction in the mind –gut axis has emerged among the important pathophysiological mechanisms for the evolution of irritable bowel syndrome (IBS).

In addition, the mind –gut liner has just been proven to be critical for the maintenance of cognitive functionality. Therefore, we analyzed the possibility of dementia after diagnosis of IBS.Employing the Taiwan National Health Insurance Research Database (NHIRD) to acquire medical claims information from 2000 to 2011, we used a random sampling approach to enroll32 298 mature patients with IBS and frequency-matched them based on gender, age, and baseline with 129 192 patients without IBS.Outcomes The patients with IBS shown an increased risk of dementia [adjusted hazard ratio (aHR) = 1.26, 95% confidence interval (CI) = 1.17–1.35]after adjustment for age, gender, hypertension, hypertension, stroke, and coronary artery disease (CAD), heart trauma, depression, and epilepsy, and the general prevalence of dementia for those cohorts with and without IBS has been 4.86 and 3.41 a 1000 person-years, respectively. IBS was correlated with a greater risk of dementia in patients older than 50 years in both female and male, and in people with comorbidity or without comorbidity. After adjustment for age, gender, and comorbidity, patients with IBS were more likely to grow either non- Alzheimer’s disease (AD) dementia (aHR = 1.24, 95% CI = 1.15–1.33) or AD (aHR = 1.76, 95% CI = 1.28–2.43).IBS is associated with a heightened risk of dementia, and this impact is evident only in patients that are ≥50 years old.