Autism spectrum disorders (ASD)

Autism spectrum disorders (ASD) are a group of biological disorders with related metabolic derangement. This analysis aimed to identify a pattern of metabolic perturbance in ASD with metabolomics in prostate specimens from 48 children with ASD and 53 age matched controls. Employing a blend of liquid- and – gas-chromatography-based mass spectrometry, we discovered the degrees of 82 metabolites (53 of which have been raised ) which were considerably changed between the ASD and the management groups utilizing osmolality compacted data. Pattern analysis revealed that the levels of many amino acids such as glycine, serine, threonine, alanine, histidine, glutamyl amino acids as well as the natural acid, taurine were significantly (p≤0.05) reduced in ASD kids. The amounts of antioxidants like carnosine were also decreased in ASD (p=0.054). What’s more, many gut bacterial metabolites were considerably altered in ASD kids who had gastrointestinal dysfunction. In general, this research found abnormal amino acid metabolism, increased oxidative stress, and modified gut microbiomes at ASD. The connection of altered gut parasitic co-metabolism along with the disrupted metabolisms requires additional investigation.

Complete Study: https://pubmed.ncbi.nlm.nih.gov/23106572/