Curcumin and Pulmonary diseases

Curcumin Utilize in Autoimmune Disorders: State of the art and future perspectivesAbstractCurcumin (diferuloylmethane) is a yellowish pigment found in the spice turmeric (Curcuma longa). It’s been utilized for centuries in Ayurveda (Indian traditional medicine) for the treatment of many ailments. Throughout the past several decades, the curative properties of curcumin have gradually been elucidated. It’s been proven that curcumin has pleiotropic effects, regulating transcription factors (e.g., NF-kB), cytokines (e.g., IL6, TNF-alpha), adhesion molecules (e.g., ICAM-1), and enzymes (e.g., MMPs) which play a significant role in inflammation and cancerogenesis. These effects might be relevant for many pulmonary diseases that are characterized by unusual inflammatory reactions, such as asthma or chronic obstructive pulmonary disease, severe respiratory distress syndrome, pulmonary fibrosis, and acute kidney disease. What’s more, some preliminary evidence indicates that curcumin might have a part in treating lung cancer. The evidence for using curcumin in pancreatic disorder remains sparse and contains largely been accessed with either in vitro or animal models. The most crucial problem by means of curcumin in people is the poor bioavailability, making it essential to utilize adjuvants or curcumin nanoparticles or liposomes. The intention of this evaluation is to summarize the available evidence on curcumin’s efficacy in autoimmune disorders, such as lung cancer, and also to provide our view on future study with curcumin in order to enhance its pharmacological consequences, in addition to provide further evidence of curcumin’s effectiveness in treating pulmonary diseases.

Details: Infection; Chronic obstructive pulmonary disease; Curcumin; Cystic fibrosis; Lung; Pulmonary fibrosis.