Curcumin and Alzheimer’s disease
Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of Both scopolamine-induced amnesia may Describe medicinal Usage of curcumin in Alzheimer’s disease
Abstract
Curcuminoids (a combination of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share critical pharmacological properties owned by garlic, a well-known curry spice, believed useful in Alzheimer’s disease (AD). The intention of this research was to assess if curcuminoids have acetylcholinesterase (AChE) inhibitory and memory improving actions. The in-vitro and ex-vivo versions of AChE inhibitory action were utilized as well as Morris water maze test to study the impact of memory . Curcuminoids inhibited AChE from the in-vitro assay using IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM. From the ex-vivo AChE assay, curcuminoids and its unique parts except curcumin revealed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus. When analyzed for their influence on memory at a certain dose (10 mg/kg), all compounds showed significant (p<0.001) and similar result in scopolamine-induced amnesia. These statistics suggest that curcuminoids and all individual parts except curcumin have marked AChE inhibitory action. Curcumin was comparatively weak from the in-vitro assay and with no impact from the ex-vivo AChE version, while both helpful in memory improving effect, suggestive of extra mechanism(s) involved. Thus curcuminoids mix might have better curative profile compared to curcumin because of its medicinal use in AD.